HLA-G with Benefits and Damages: A Review

Abstract

Human leucocyte antigen-G (HLA-G) is a non-classical HLA that researchers primarily focused on association with the complications of pregnancy. Recent studies about the immunomodulatory characteristics of HLA-G showed that this molecule is not only important in pregnancy but also have effects on transplantation, autoimmune diseases, cancer and infectious diseases. The restricted polymorphic nature and the disease association has also showed in various studies. In this review it was aimed to evaluate the benefits and damages of the HLA-G by considering both the expression levels and polymorphisms.