The effect of tamoxifen on serum lipid, lipoprotein and estradiol in women with breast cancer

Tamoksifen tedavisinin meme kanserli kadınlarda serum lipid, lipoprotein ve östradiol düzeylerine etkisi

E. Gökhan KANDEMİR, Hayati TOR, Mustafa YAYLACI, Bülent BOR, Necdet ÜSKENT, M. Emin ÖNDE

Abstract

In this study the effects of tamoxifen (Tmx) on serum lipids lipoproteins and estradiol were investigated in patients (pts) treated with Tmx on adjuvant setting Thirty-one women with breast cancer (11 premenopausal 20 postmenopausal ) were included in the study Be fore and at the 3rd 6th 9th and 12th months of Tmx therapy, the serum levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), trigliseride (TG), apolipoprotein A-I (Apo A-l), apolipoprotein A-II (Apo A-ll), apolipoprotein B (Apo B) and total estradiol were measured and LDL-C/HDL-C, HDL-C/TC ratio were calculated. At the 12th month, serum levels of TC, LDL-C, Apo B and LDL-C/HDL-C ratio decreased significantly (23%, 43%, 22% and 31%, respectively); serum levels of Apo A-l, Apo A-II, HDL-C and HDL-C/TC ratio increased significantly (40%, 40%, 11.6%, and 46%, respectively). There were no statistically significant differences in TG values. While the serum estradiol levels of premenopausal pts showed significant increments (p0.05). Our results indicate that long term treatment with Tmx changing the lipidic picture may lower the risk of coronary heart disease.

Özet

Bu çalışmada 11 premenopozal, 20 postmenopozal meme kanserli 31 olguda tamoksifen (Tmx tedavisinin serum lipid, lipoprotein ve Östradiol düzeylerine etkisi araştırılmıştır. Tedavi öncesi ve tedavi sonrası 3., 6., 9. ve 12. aylarda serum total kolesterol (TK), HDL-kolesterol (HDL-K), trigliserid (TG), apolipoprotein A-I (Apo A-l), apolipoprotein A-II (Apo A-ll), apolipoprotein B (Apo B) ve total Östradiol düzeyleri ölçülmüş ve serum LDL-kolesterol (LDL-K) düzeyi, LDL-K/HDL-K oranı, HDL-K/TK oranı hesaplanmıştır. Bazal değerlerle karşılaştırıldığında bakılan parametrelerde 6. aydan itibaren değişiklikler görülürken, 12. ayda istatistiksel olarak anlamlılık kazanmıştır. Onikinci ayda serum TK, LDL-K, Apo B düzeylerinde ve LDL-K/HDL-K düzeylerinde ve HDL/TK oranında ise anlamlı artış saptanmıştır (sırasıyla, %40, %40, %11.6 ve %46, p