Lipid peroxidation, zinc and magnesium concentrations in hypertensive patients

İlhan YAYLIM, Bedia AGAÇHAN, Makbule AYDIN, Hülya YILMAZ, Turgay İSBİR, Oğuz ÖZTÜRK

Abstract

The aim of the study was to evaluate lipid peroxidation, zinc and magnesium concentrations in plasma of essential hypertensive patients. The levels of lipid peroxidation, measured as thiobarbituric-acid reactive substance (TBARS), zinc and magnesium were measured in plasma of 30 patients with hypertension and in 27 normotensive controls. The concentration of plasma TBARS was measured by a thiobarbituric acid test. The levels of TBARS in plasma of patients were significantly higher than in the normotensive control group. There were no significant differences in plasma zinc and magnesium between these groups. Increased oxidative stress may contribute to endothelial dysfunction in hypertensive patients, so that free radicals seem likely to play a role in the pathogenesis of essential hypertension.

Özet

Bu çalışmanın amacı esansiyel hipertansif hastalarda lipid peroksidasyonu, çinko ve magnezyum konsantrasyonlarını tayin etmektir. Lipid peroksidasyonu, thiobarbituric-acid reactive substance (TEARS) olarak, çinko ve magnezyum seviyeleri 30 hipertansit hastada ve 27 normotensif kontrolde ölçüldü. Plazma TBARS seviyeleri tiyobarbitürik asid testi ile ölçüldü. Hipertansif hastalardaki TBARS değerleri kontrollere göre istatistiki olarak anlamlı derecede yüksek bulundu. Çinko ve magnezyum değerlerinde anlamlı bir fark bulunamadı. Artmış oksidatif stres hipertansif hastalarda endotelyal hasara katkıda bulunabilir. Böylece serbest radikallerin esansiyel hipertansiyonun patogenezinde rol oynadığı düşünülmektedir.