The Role of Whole Blood Viscosity Estimated by De Simone’s Formula in Evaluation of Fractional Flow Reserve

Abstract

Objectives: Fractional flow reserve (FFR), which is an invasive technique, is appraised as the gold standard for physiological valuation of intermediate coronary disease. Because it is a pressure-linked measure, FFR can be influenced by whole blood viscosity (WBV). We aimed to evaluate the relationship between FFR and WBV, which can be calculated by a confirmed formula using only hematocrit and total serum protein levels. Materials and Methods: We involved 226 patients who were implemented FFR after interpreting coronary artery angiogram. We separated the patients into two groups accordingly with the FFR cutoff value of 0.80: 96 patients (77.1% male, mean age 62.84±9.90 years) with critical stenosis as FFR