Could diabetes mellitus be a risk factor for postoperative hypoparathyroidism?

Diabetes mellitus postoperatif hipoparatiroidizm için bir risk faktörü olabilir mi?

Abstract

Aim: Postoperative hypoparathyroidism (postop hypoPT) is usually seen after aggressive neck surgery, and can be fatal if left untreated. To the best our knowledge there is no study in literature that directly investigates the association between diabetes mellitus (DM) and postop hypoPT. In this study, we aimed to determine whether DM increases the risk of permanent postop hypoPT. Materials and Methods: Patients presenting to endocrinology outpatient clinic with a diagnosis of permanent postoperative hypoparathyroidism, were studied retrospectively. Patients older than 18 years of age were included in the study if one year had passed after the neck operation. Results: The average age of 131 patients who met the inclusion criteria was 49 ± 12. 93.9% of the patients were women and the patients were generally obese or overweight (mean body mass index= 30±5.29 kg/m2). While 14.5% of the patients were diabetic and 32.8% prediabetic (47.3% had impaired carbohydrate tolerance), 52.7% had normal glucose metabolism. Conclusion: The rate of DM / prediabetes (preDM) in patients diagnosed with postop hypoPT and the prevalence of DM / preDM in Turkish population were similar. Even though DM is associated with endothelial dysfunction, our findings suggest that DM is not a risk factor for postop hypoPT.

Özet

Amaç: Postoperatif hipoparatiroidizm (postop hipoPT) genellikle agresif boyun cerrahisinden sonra görülür ve tedavi edilmezse ölümcül olabilir. Bildiğimiz kadarıyla literatürde diabetes mellitus (DM) ile postop hipoPT arasındaki ilişkiyi doğrudan araştıran bir çalışma bulunmamaktadır. Bu çalışmada DM'nin kalıcı postop hipoPT riskini artırıp artırmadığını belirlemeyi amaçladık. Gereç ve Yöntem: Endokrinoloji polikliniğine postoperatif kalıcı hipoparatiroidizm tanısı ile başvuran hastalar retrospektif olarak incelendi. Boyun ameliyatının üzerinden en az bir yıl geçmiş olan 18 yaş üstü hastalar çalışmaya dâhil edildi.