Pleuropericardial Effusion: A Rare Onset of Rheumatoid Arthritis

Abstract

Pulmonary involvement is one of the most common extra-articular findings in rheumatoid arthritis (RA) where parenchymal lung disease and pleural disease are reported to be up to 79% and 50%, respectively.1 Recent data suggests that RA-related autoimmunity may initiate in a mucosal site many years before the onset of joint symptoms, suggesting that the lung is one of these mucosal sites.2 A 68-year-old male patient was admitted with dyspnea and chest pain that had started a week earlier. Lung sounds had decreased on the middle and lower zone of right lung on auscultation and chest X-ray revealed bilateral pulmonary effusion which was more prominent on the right lung. Pleural fluid reached a thickness of 9 cm on the right and 2 cm on the left, sub-segmental atelectasis, septal thickening and pericardial effusion were observed on chest computed tomography. Laboratory tests marked for normocytic anemia (hemoglobin: 9.0 g/ dL), leukocytosis [white blood cell (WBC): 16,200/μL] and elevated acute phase reactants, erythrocyte sedimentation rate (ESR): 98 mm/h and C-reactive protein (CRP): 143 mg/dL (normal: 0–5 mg/L). Transthoracic echocardiography showed an ejection fraction of 65%, and a moderate pericardial effusion which measured 14 mm at its widest point. Sputum microscopy, sputum acido-resistant basil and sputum culture tests were negative for the exclusion of tuberculosis and other possible infections. Thoracentesis was performed and pleural fluid was exudative, pleural adenosine deiminase and mycobacterium polymerase chain reaction were negative. In pleural fluid cytology, 60% lymphocytes and 40% polymorphonuclear leukocytes were observed, and no microorganisms or malignant cells were found. ANA was positive at 1/100 titer of chromosomal dense fine speckled (DFS) pattern. Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody were positive at high titers 108.5 IU/mL (normal: 0–7 IU/mL) and 195.6 U/mL (normal: