ITERATED BOOTSTRAP PROCEDURE IN INDIVIDUAL BIOEQUIVALENCE

Abstract

In this paper, we propose an iterating principle in the bootstrapmethod to assess the individual bioequivalence under 24 randomized crossoverdesign. The Önite sample properties of the proposed algorithm are illustratedby an extensive simulation study and a real-world example. Our Öndings revealthat the proposed idea have better performance than the classical percentilebootstrap conÖdence limits.