Acute infectious exacerbations in chronic obstructive lung disease and effects of azithromycine, sultamycilline, ciprofloxacin and cefaclor monohydrate

Kronik obstrüktif akciğer hastalığı olgularında akut infeksiyon döneminde patojen ajanın saptanması ve azitromisin, sultamisilin, siprofloksasin ve sefaklor monohidratın etkinliği

Nurhayat YILDIRIM, Filiz KOŞAR, Haluk VAHABOĞLU, Sema UMUT, Füsun SOYSAL, Veli GÖYLÜSÜN, Bülent TUTLUOĞLU, Mübeccel AKMAN, Mustafa ERELEL, Aygün GÜR, Nail YILMAZ, Sibel UNUTMAZ, Benan MÜSELLİM, Günay Aydın TOSUN, Müzeyyen ERK, Yılmaz Tülin KUYUCU, Orhan ARSEVEN, Veysel YILMAZ, Ahmet İLVAN, Sami ÖZTÜ

Abstract

Background and Design.- Lower respiratory tract infections cause great morbidity and morta¬lity in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to find out the causative organism and the effects of azit-romycine, ampicilline sulbactam (sultamycilline), ciprofloxacine and cefaclor monohydrate therapy in COPD. One hundred and sixteen patients with COPD in acute exacerbation were randomized in¬to four groups for antibiotic treatment following lung function test and sputum. Results - The most common strains were H. inf-luenzae (30.8%), S. pneumoniae (12.0%) and M. catarrhalis (7.7%). Conclusion. - H. influenza is the most common causative organism in acute infectious attacks of COPD. Azithromycine, ampicilline sulbactam (Sul¬tamycilline), ciprofloxacine and cefaclor monohyd¬rate are of value in the treatment of acute infection.