Codeine-Induced Syndrome of Inappropriate Antidiuretic Hormone: Case Report

Abstract

Background:Thesyndrome ofinappropriate antidiuretic hormonewasfirstdescribed in 1957 bySchwartz, andis characterised byhy-ponatraemia, inappropriately increased urine osmolality andurine so-dium, anddecreased serum osmolality in a euvolemic patient withoutedema. A patient withthesyndrome ofinappropriate antidiuretic hor-mone should havenormal cardiac, renal, adrenal, hepatic, andthyroidfunctions and should not take any diuretics.Case Report:Wepresent a caseofthesyndrome ofinappropriateantidiuretic hormone caused bycodeine andassociated withreducedurine volume, increased urine sodium, anddecreased serum sodiumconcentration.Conclusion:Thesyndrome of inappropriate antidiuretic hormone is a disease thatcanleadto morbidity andevenmortality. Clinicians shouldmeasure serum electrolytes intermittently in order to avoid missing the diagnosis of thesyndrome of inappropriate antidiuretic hormone in pa-tients using opioid.