Evaluation of Postoperative Anti-nociceptive Efficacy of Intrathecal Dexketoprofen in Rats

Abstract

Background: Some studies have suggested that the intrathecaluse of cyclooxygenase enzyme inhibitors providesan anti-nociceptive effect. Therefore, the occurrence of sideeffects seen in systemic usage can be eliminated.Aims: The primary objective of this experimental, randomized,controlled trial was to test the hypothesis asserting thatintrathecal dexketoprofen trometamol would demonstratean analgesic effect during postoperative period.Study Design: Animal experimentation.Methods: Forty rats were randomized into 4 groups 7 daysafter intrathecal catheterization; the following drugs weregiven through catheter lumens: Group Lidocaine (Group L):Lidocaine 20 ?g; Group Lidocaine-Morphine (Group LM):Lidocaine 20 ?g and morphine 0.5 ?gr; Group LidocaineDexketoprofen(Group LD): Lidocaine 20 ?g and dexketoprofentrometamol 100 ?g; and Group Dexketoprofen(Group D): Dexketoprofen trometamol 100 ?g. Paw incisionwas achieved under ether inhalation. To measure analgesicpotential, hot plate and tail immersion tests were usedas nociceptive tests during the postoperative period.Results: The mean reaction times detected in groups duringhot plate and tail immersion tests were shortest in Group Lat 15, 30, 45, 60, 75, 90, 105, and 120 minutes after startof surgery (p