Correlation of Serum CCL3/MIP-1α Levels with Disease Severity in Postmenopausal Osteoporotic Females

Abstract

Background: The pro-inflammatory protein chemokine cytokineligand 3 is well established as a vital regulator of bone resorption andosteoclast stimulation.Aims: To investigate if serum cytokine ligand 3 levels correlated withdisease severity in postmenopausal osteoporotic women.Study Design: Cross-sectional study.Methods: Eighty-two postmenopausal osteoporotic women, 76postmenopausal non-osteoporotic women, and 80 healthy womenof childbearing age were recruited. The total hip, femoral neck, andL1-L4 spine bone mineral density were assessed by dual-energyX-ray absorptiometry. Serum cytokine ligand 3 concentrations wereexamined using a commercial enzyme-linked immunosorbent assaykit. Serum inflammatory cytokine interleukin-6, tumor necrosis factoralpha,and the bone metabolic markers, carboxy-terminal crosslinkedand tartrate-resistant acid phosphatase 5b were also examined. Scoreson both the visual analogue scale and the Oswestry Disability Indexwere utilized to assess clinical severity.Results: Patients in the postmenopausal osteoporotic group hadsignificantly increased serum cytokine ligand 3 levels compared withthose in both the postmenopausal non-osteoporotic group (40.9±15.1pg/mL vs 24.2±8.7 pg/mL, p