miR-19a-3p Functions as an Oncogene by Regulating FBXO32 Expression in Multiple Myeloma

Abstract

Background: Multiple myeloma remains a virtually incurable hematologic malignancy, which is featured with the aberrant growth of malignant plasma cells.Aims: To elucidate the functions of miR-19a-3p in multiple myeloma.Study Design: Cell study.Methods: Cell counting kit-8 assay was performed to detect cell viability, and flow cytometry was conducted to detect cell apoptosis. Bioinformatics analysis predicted miR-19a-3p-associated biological function, pathway, core regulatory network, and target genes. Luciferase reporter assay verified the target sequence of miR-19a-3p regulating FBXO32.Results: miR-19a-3p is upregulated in multiple myeloma cells (p