The importance of estrogen-α and progesterone immunohistochemical staining expression in patients with papillary thyroid carcinoma

Abstract

Aim: Estrogen receptor-α(ERα) and Progesterone receptor(PR) were studied in 58 patients who were diagnosed as papillary thyroidcarcinoma in our hospital between 2011 and 2013.ERα and PR expression patterns were compared according to age, sex, tumorsubtype, metastasis, focality and tumor size.Material and Methods: ERα and PR immunohistochemical staining were performed on a Ventana Benchmark XT device.More than10% expression of ERα and PR immunohistochemical stains in the tumor field was considered positive.Results: Papillary thyroid cancer is the most common type of endocrine malignancy in females and it is approximately three timesmore common among females than males. Given that these lesions are more common in women than men and that the rate decreasesafter menopause, sex steroid hormones are thought to play a role in the etiology of the benign and malignant lesions of the thyroid. .Conclusion: The findings in our study support many studies in the literature, and there is a significant relationship between tumorsize, tumor stage, and metastasis and ERα and PR immunohistochemical expression.However, more studies are still needed toevaluate the effect of ERα and PR on thyroid papillary cancers.