Chromosome analysis results of first-second trimester anomaly screening tests: Single center experience

Abstract

Aim: The Objective of our study was to evaluate the chromosomal analysis results that were obtained from amniocentesis,cordocentesis and chorionic villus sampling (CVS) inpatients whom had applied to the perinatology unit of Cukurova UniversityFaculty of Medicine gynecology and obstetrics clinic with high risk in terms of chromosome anomaly according to Ultrasonography(USG).Material and Methods: Our study was conducted as a retrospective pattern. CVS, amniocentesis and cordosentesis were performedin 1298 pregnant women whom had applied to the Çukurova University Faculty of Medicine, Gynecology and Obstetrics Clinic,Perinatology Unit in the date interval between 1st December 2014-31st December 2016 with the indication of abnormal maternalserum screening tests, maternal request because of advanced maternal age, history of fetal anomaly with previous pregnancies,history of relatives with Trisomy 21, fetal abnormalities or signs of trisomy which were detected by ultrasonography and onlydepending on maternal request without any risk factors. Data obtained in the study were assessed using the SPSS (StatisticalPackage for Social Sciences) 22.0 package program. The relationships between categorical variables were determined by ChiSquare test. Relationship between normal distribution-matched, numerical data were assessed by ANOVA, Independent Samplet-test, and relationship between non-normal distributions of numerical data were assessed using Mann-Whitney U and WilcoxonTest. Statistical significance level was determined as p