Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?

Abstract

Aim: To evaluate the effect of coexistent extracapsular extension and seminal vesicle invasion on biochemical reccurence freesurvival rates in patients who had undergone open radical retropubic prostatectomy.Material and Methods: The data of 307 patients with clinically localized prostate cancer who had undergone radical retropubicprostatectomy between January 2000 and May 2019 were evaluated retrospectively. According to extension of tumor on surgicalspecimens, patients were classified into five groups as; organ-confined disease, extracapsular extension, isolated seminal vesicleinvasion, extracapsular extension in addition to seminal vesicle invasion and lymph node involvement. Patient groups were analyzedcategorically with regard to biochemical reccurence free survival rates by using Kaplan Meier analysis, log-rank and chi-squaretests. The effect of pathological features of surgical specimens on biochemical reccurence was evaluated by using univariate andmultivariate Cox regression analysis.Results: There were statistically significant differences on biochemical reccurence free survival rates among the five groups, andpathological stage and biochemical reccurence rates increased correspondingly. Multivariate Cox regression analysis showed thatcoexistent extracapsular extension and seminal vesicle invasion, and lymph node involvement are the two significant factors thatnegatively effect the biochemical reccurence free survival rate.Conclusion: Coexistence of extracapsular extension and seminal vesicle invasion is a worse prognostic factor compared to theirisolated forms.