The value of blood parameters as a diagnostic inflammatory biomarker for inverted papilloma

Abstract

Aim: We aimed to determine the diagnostic value of blood parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-tolymphocyte ratio (PLR) and mean platelet volume (MPV) values for sinonasal inverted papilloma (IP) and to investigate its relationshipwith severity of the disease.Material and Methods: In this retrospective study, 33 patients (22 males, 11 females; mean age 52.60±8.99 years) diagnosed with IPand 44 healthy individuals (25 males, 19 females; mean age 50.97±9.28 years) were included. NLR, PLR and MPV values of IP andcontrol groups were calculated and compared statistically. In IP group, NLR values and stages of the disease in accordance with theKrouse Staging system were evaluated statistically.Results: NLR levels were significantly higher in the IP group than the control group. (Mean NLR: IP group= 2,484±1.132; Controlgroup= 1.971±0.884; p=0.029). Lymphocyte, PLR and MPV values were not statistically significant between the two groups. A strongcorrelation was found between the NLR value and IP stages.Conclusion: In cases with inverted papilloma, the NLR value obtained by easy-to-perform and low-cost tests, can be used as anew inflammatory biomarker and to predict the severity of the disease. In order to confirm these findings, further studies with largerpatient series are needed.