Can platelet Iymphocyte ratio and neutrophil to lymphocyte ratio be used as prognostic predictors for hepatocellular carcinoma?

Abstract

Aim: To investigate the predictive value of platelet to lymphocyte and neutrophil to lymphocyte ratios for hepatocellular carcinomaoutcomesMaterial and Methods: 37 hepatocellular carcinoma patients were retrospectively collected. All of the hepatocellular carcinomapatients were treated with conventional methods; transarterial chemoembolization, radiofrequency ablation or both. The patientand tumor characteristics, platelet to lymphocyte ratio and neutrophil to lymphocyte ratio were recorded. The association betweenplatelet to lymphocyte ratio and neutrophil to lymphocyte ratio and tumor free survival rates, recurence rates, need of repeatedconventional therapy were analyzed.Results: The mean MELD (model for end stage liver disease) score of 37 hepatocellular carcinoma patients was 10.75±4.484(mean age 59.59±17.23 years). High platelet to lymphocyte ratio and neutrophil to lymphocyte ratio were found to be associatedwith hepatocellular carcinoma recurrence (p0.05). Platelet to lymphocyte ratio and neutrophil to lymphocyte ratios were significantlyhigh in patients who had repated transarterial chemoembolisation, radiofrequency ablation or both (p