Comparison of the effects of dexmedetomidineremifentanil and propofol-remifentanil combinations on postoperative cognitive functions in patients undergoing hysteroscopy: A randomized prospective study

Abstract

Aim: In the present study, we aimed to compare Dexmedetomidine-Remifentanil and Propofol-Remifentanil combinations in termsof postoperative cognitive functions in hysteroscopy attempts.Material and Methods: A total of 70 ASA I-II patients who were aged between 18 and 65 years were included in the study followingthe ethics committee approval. The patients were randomized into two groups (n=35), and standard routine monitoring were appliedto them. The sedation depth was evaluated with Ramsey Sedation Score (RSS) before and after the sedation; and cognitive functionsof the groups were evaluated with the Minimal Mental State Test (MMST).Propofol 1 mg/kg bolus 25-100 μg/kg/min infusion was administered to Group PR, and Dexmedetomidine 1 μg/kg bolus 0.4-0.7 μg/kg/h infusion dose was administered to Group DR. Remifentanil 0.25 μg/kg bolus 0.04 μg /kg/min infusion was administered to thegroups, and the groups were followed to ensure RSS≥4.Result: In cognitive functions, it was observed that there was significant regression in Group PR in postoperative period comparedto the preoperative period (p