Clinicopathological characteristics and prognosis of gastric adenocarcinoma patients

Abstract

Aim: It was aimed to examine the clinicopathological characteristics of gastric adenocarcinoma patients detected in our center, todetermine their prognosis and to present our experience.Material and Methods: Eighty patients with primary gastric adenocarcinoma who had undergone gastrectomy operation betweenthe years 2011 and 2015 were included in the study. The clinicopathological characteristics of the patients were evaluated. Theparameters examined in the patients were age, gender, localization of tumor, histological type, the degree of differentiation, lymphaticinvasion, perineural invasion, lymph node metastasis, depth of tumor invasion, tumor stage, and postoperative prognosis indexes.Results: The average age of 80 patients with primary gastric adenocarcinoma was 70, and the age range was 33-86. Our patientsconsisted of 48 males and 32 females. Of the patients, 72.5% were the intestinal type, 17.5% were the diffuse type, and 10% werethe mixed type. While 11.3% of the tumors were well differentiated, 46.3% were moderately differentiated, and 42.5% were poorlydifferentiated. 82.5% of the patients had a lymphatic invasion, 70% had a perineural invasion, and 82.5% had lymph node metastasis.While 65.0% of the patients had localization in the distal of the stomach, 35.0% of them had proximal localization. While serosainvasion was observed in 85.0% of the patients, mucosal invasion and muscularis propria invasion were observed in 5.0% and 10.0%of the patients, respectively. Of all the patients, six were stage I, 15 were stage II, and 59 were stage III. It was determined that overallsurvival (OS) was 15 months and recurrence- free survival (RFS) was 14 months.Conclusion: Distal localization was more common in gastric adenocarcinomas. When gastric cancers were detected, they wereusually advanced stage, and the prognosis was poor. Therefore, early diagnosis is important.