Comparison of Cerb B2 expression and Ki-67 index with modifid scarff-bloom-richardson grading system in invasive ductal carcinoma

Abstract

Aim: Breast cancer is the most frequent cancer among women. Cerb B2 is an oncogene that encodes a transmembrane glycoproteinknown as HER-2 protein or receptor. Ki-67 is nuclear protein associated with cellular proliferation. In this study, we investigatedthe relationships between the histopathologic parameters in the “Modifid Scarff-Bloom-Richardson” microscopic grading andexpression of Cerb B2 and Ki-67 index gene in cases with invasive ductal carcinoma. Breast cancer is the most common type ofcancer in women, but also the second most common cause of death after lung cancer.Material and Methods: In this study examined 45 patients who were diagnosed with invasive ductal carcinoma between January2017 and January 2019 in Sivas Cumhuriyet University, department of surgical oncology. Cases, Cerb B2 expression and Ki-67 indexwere retrospectively screened from pathology recordsResults: Increased expression of Cerb B2 was statistically signifiant related with increased tubule formation, pleomorfim, mitosisrate, and histological grade (p=0.006, p=0.027, p