Evaluation of factors related to postoperative mortality in patients who underwent pancreatoduodenectomy due to periampullary region tumors

Abstract

Aim: In this study, we aimed to investigate the factors related to postoperative mortality after pancreatoduodenectomy in our clinic.Materials and Methods: Patients who underwent pancreatoduodenectomy due to a periampullary region tumor between 2010 and2019 were included in the study. Mortality that occurred within 30 days after PD was defined as postoperative mortality and groupswere formed according to this definition Group 1(Postoperative Mortality) and Group 2(No mortality). The demographic and clinicalfeatures, laboratory parameters, and tumor features of the patients were compared between the groups. Risk factors for mortalitywere analyzed by univariate analysis and multivariate logistic regression analysis.Results: 155 patients participated in our study. We found our postoperative mortality rate as 11.6%. Accordingly, Group 1 consistedof 18 and Group 2 consisted of 137 patients. The sex was similar (p: 0.235). The average age was higher in Group 1 than 2 (71.2 vs63.7, p:0.013). Tumor localizations were similar in groups (p:0.275). Lymph node positivity was similar in the groups (50% vs 41.6%,p:0.333). The pancreatic fistula was higher in Group 1, but not statistically significant (33% vs 18.2%, p:0.119). Preoperative whiteblood cell count (9490 mm3 vs 8050 mm3) and neutrophil count (6898 mm3 vs5442 mm3) were higher in Group 1. In multivariateanalysis, no parameters were single-handedly risk factors.Conclusion: No factor was found to be effective alone in the development of mortality after pancreaticoduodenectomy. We think thatpostoperative mortality may decrease by revealing the factors in the preoperative, intraoperative and postoperative periods.