Prognostic importance of progesterone receptor expression in meningioma

Abstract

Aim: : In this study, our objective was to demonstrate the relationship of progesterone receptor (PR) expression with histologicalgrade and other prognostic factors in patients with meningiomas.Material and Methods: Brain biopsy materials, which were examined and diagnosed with meningioma between January 2011 andJanuary 2015, were screened in a retrospective study design. Ninety-six of the cases, who were diagnosed with meningioma with agrade of I, II, and III according to WHO and had undergone immunohistochemically PR expression, were included in the study.Results: JThere was a weak correlation between WHO grade and PR expression rate and intensity in our study. PRexpression rate and intensity showed increment as the grade progressed. On the other hand, there was no correlationof PR expression rate and intensity with other prognostic parameters such as Ki67 proliferation index and mitotic index.Conclusion: Although we have detected a weak correlation between PR expression rate and intensity with WHO grade, we thinkthat PR expression rate and intensity do not have prognostic role in the meningiomas due to the absence of a similar relationshipbetween other important parameters in prognosis. In most of the studies in the literature, it is reported that PR expression rate andintensity decreases with increasing WHO grade. However, the number of studies with the opposite results is high. In the presence ofconflicting data in the literature and considering that almost all of these studies were performed according to the WHO classificationbefore 2016 (before the new WHO classification), we concluded that further multi-centre studies utilizing new classification systemand have more homogeneous distribution of the grades are required to investigate the relationship between PR and histopathologicgrade and other prognostic parameters.