The effect of neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and mean platelet volume to thrombocyte ratio (MPV/PLT) on survival in myelodysplastyc syndrome

Abstract

Aim: The aim of the study is to evaluate the relationship between age and leukocyte subtype ratio and their effects on survival in patients diagnosed with myelodysplastic syndrome (MDS). Materials and Methods: We retrospectively examined total of 101 patients diagnosed with MDS between January 2010 and June 2020. The patients were analysed by dividing into two groups; < 70 years and ≥70 years. Results: The median of overall survival was significantly higher in < 70 years’ group (96 vs 40 month, OR 3.6; 95% CI, 1.6-8.7, p < 0.001). Whereas neutrophil-to-lymphocyte ratio (NLR) was significantly higher in ≥70 years group, lymphocyte-to-monocyte ratio (LMR) was significantly higher in < 70 years group (p = 0,013 and p = 0,041, respectively). NLR was positively correlated with age (rho: 0.27, p = 0.007) but negatively correlated with clinical risk (rho: -0.24, p = 0.018), MPV/PLT ratio was positively correlated with IPSS group (rho: 0.40, p < 0.001). In multivariate analysis, its found that age and IPSS group effects overall survival. HR was 1.064 (95% CI; 1.033-1.096, p < 0.001) for age and was 3.664 (95% CI; 1.285-10.445, p < 0.015) for IPSS group (low versus intermediate-2). Conclusion: We concluded that NLR and LMR may have a prognostic value for patients who are ≥70 years diagnosed MDS.