Ga-68 DOTATATE Positron Emission Tomography Computed Tomography Findings in Patients with Neuroendocrine Tumor Suspicion

Nöroendokrin Tümör ?üphesi Olan Hastalarda Ga-68 DOTATATE Pozitron Emisyon Tomografisi/Bilgisayarl Tomografi Bulgular

Abstract

Aim: We aimed to retrospectively evaluate the outcome of patients with suspected neuroendocrine tumor (NET)s who underwent Ga-68 DOTATATE Pozitrun Emission Tomography/Computed Tomography (PET/CT) imaging and to describe the value of Ga-68 DOTATATE PET/CT in the detection of NETs. Material and Method: Ga-68 DOTATATE PET/CT images of 35 patients (26M; 9F, mean age; 45.2±5.4 years) with suspected NET were analyzed retrospectively. Suspicion of NET was due to clinical symptoms (n:12), elevated biochemical markers (n:19) and/or radiological findings (n:13). Clinical/imaging follow-up and/or histopathological confirmation was used as reference standard. Results: Based on the reference standard 13 of 35 patients had NET. Ga-68 DOTATATE PET/CT was positive in 12 out of 13 patients and it was false negative in 1 patient. Pancreas was the commonest site of the primary tumor. Ga-68 DOTATATE was TP(true pozitive), FP (False Positive), TN (True Negative) and FN (False Negative) in, 12, 2, 20 and 1, patients respectively. Sensitivity, specificity, Pozitive Pedictive Value (PPV), Negative Pedictive Value (NPV), and accuracy of Ga-68 DOTATATE PET/CT was calculated as 85%, 95%, 92%, 90% and 91%, respectively. Conclusion: Ga-68 DOTATATE PET/CT has a high accuracy in the detection of suspected NET. It can be used for searching possible NET in patients with suspicion.

Özet

Amaç: Nöroendokrin Tümör (NET) Lüphesi ile Ga-68 DOTATATE Pozitron Emisyon Tomografisi/Bilgisayarl Tomografi (PET/BT) görüntüleme yap lan hastalar n sonuçlar n retrospektif olarak de?erlendirmeyi ve NET saptanmas nda Ga68 DOTATATE PET/BT'nin yerini tan mlamay amaçlad k. Gereç ve Yöntem: Nöroendokrin tumor Lüphesi ile Ga-68 DOTATATE PET/BT yap lan 35 hastan n (26E; 9K, ort. yaL; 45.2±5.4) sonuçlar retrospektif olarak analiz edildi. Nöroendokrin tumor Lüphesi klinik bulgular (n:12), biyokimyasal parametrelerde yükselme (n:19) ve radyolojik bulgular (n:13) idi. Klinik/radyolojik takip ve/veya histopatolojik inceleme referans standart olarak kullan ld . Bulgular: Referans standart temel al narak 35 hastan n 13'ü NET olarak kabul edildi. Ga-68 DOTATATE PET/BT 13 hastan n 12'sinde pozitif ve 1'inde yalanc negative idi. En s k primer tümör lokalizayonu pankreas idi. Ga-68 DOTATATE PET/BT 12, 2, 20 and 1 hastada s ras ile Gerçek Pozitif (GP), Yalanc Pozitif (YP), Gerçek Negatif (GN) ve Yalanc Negatif (YN) idi. Ga-68 DOTATATE PET/BT için duyarl l k, özgüllük, pozitif pediatrig de?er, negatif pediatrik de?er ve do?ruluk s ras ile %85, %95, %92, %90 ve %91% olarak hesapland . Sonuç: Ga-68 DOTATATE PET/BT NET Lüphesinde tümör oda? n n saptanmas nda yüksek do?rulu?a sahiptir ve bu amaçla kullanlabilir.