Journals / Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2019 / Cilt: 52 - Sayı: 3
EVALUATION OF GLEASON SCORE RESULTS FROM NEEDLE BIOPSY AND RADICAL PROSTATECTOMY SPECIMENS IN PROSTATE ADENOCARCINOMA
- Pages
- 222–226
- DOI
- —
Abstract
PURPOSE: In this study, needle biopsy (IB) and radical prostatectomy (RP) materials in prostate adenocarcinoma were compared histopathologically and it was aimed to evaluate compliance of Gleason score and grade group classifications which are important in prognosis. Material and Method: RP and IB materials of 42 patients who were diagnosed as prostate adenocarcinoma between 2013 and 2018 in Kırıkkale University Medical Faculty Medical Pathology Department were evaluated histopathologically. Results: The mean age of the 42 patients included in the study was 61.1 (48-79) years and serum PSA levels were 4 ng / ml (0.03- 26.320 ng/ml). Thirty patients had a one-to-one match in the IB and RP Gleason scores, and one different grade score in 12 patients. Similarly, in RP material, in 6 (14.2%) patients, grade group score was decreased compared to IB (low score, down-grade) and in 8 (19%) patients increased (high score, up-grade) and one-to-one compliance was observed in 28 (66.6%) of the patients. When the Gleason (p
Özet
Amaç: Bu çalışmada, prostat adenokarsinomunda iğne biyopsi (İB)ve radikal prostatektomi (RP) materyalleri, histopatolojik olarakkarşılaştırılarak, prognozda önem arz eden Gleason skor ve gradegrup sınıflamalarının uyumunun değerlendirilmesi amaçlandı.Gereç ve Yöntem: Kırıkkale Üniversitesi Tıp Fakültesi TıbbiPatoloji Anabilim Dalı’nda, 2013-2018 yılları arasında 42 adet,prostat adenokarsinomu tanısı almış olan hastaya ait RP ve İBmateryalleri histopatolojik olarak değerlendirildi.Bulgular: Çalışma kapsamındaki 42 olgunun ortalama yaşı 61,1(48-79) ve serum PSA düzeyleri 4 ng/ml (0,03-26,320 ng/ml) idi.Otuz olguda İB ve RP Gleason skorlarında birebir, 12 olguda ise 1grade skoru farkla uyum tespit edildi. Benzer şekilde RP materyalindede 6 (%14,2) hastada grade grup skorunda İB’ye göre azalma (düşükskor verme, down-grade), 8 (%19) hastada ise artma (yüksek skorverme, up-grade) belirlenirken 28 (%66,6) hastada ise birebir uyumsaptandı. RP ve İB örneklerinde Gleason (p