PERINATAL OUTCOMES OF GESTATIONAL THYROTOXICOSIS: SINGLE CENTER EXPERIENCE, RETROSPECTIVE COHORT

Abstract

PURPOSE: Gestational thyrotoxicosis may lead to adverse maternaland fetal events. In this study, the aim was to compare the gestationalthyrotoxicosis cases with the control group in terms of their differentialdiagnoses, clinical observation and gestational follow-up outcomes.MATERIAL AND METHODS: Pregnant patients with subclinicalor overt thyrotoxicosis who were followed up in Endocrinologyoutpatient clinic between December 2009-September 2019 wereincluded in the study. Patients were grouped according to thediagnosis of gestational transient thyrotoxicosis (GTT), Graves’disease, toxic nodular goiter (TNG), and intra-group comparisonsand comparisons with the control group were made in terms of thepresence of perinatalcomplications during the gestational period,delivery week, and birthweight.RESULTS: A total of 115 patients were divided into GTT group,which had 50 patients, Graves’ group, which had 14 patients, TNGgroup, which had 1 patient, and control group, which had 50 patients.The prevalence of hyperemesis gravidarum was the highest in GTTgroup, with 40%. Eclampsia was found in 2 (14.2%) of the pregnantwomen with Graves’ disease and was not found in other groups(p=0.01). Neonatal death was found in 3 (21.4%) of the pregnantwomen with Graves’ disease, and 1 (2%) of the pregnant women withGTT (p=0.01). There was a significant positive correlation betweendelivery week and TSH (p=0.001, r:0.64), and a significant negativecorrelation withft3(p=0.04 r:-0.3). A significant positive correlationwas detected between birthweight and TSH and delivery week(p=0.03 r:0.32 and p