Manic Episode as a Result of Adding Trazodone to a Patient under Escitalopram Treatment

Abstract

Antidepressants with hypnotic effects can often be added to treatment for sleep prob-lems emerging in patients receiving antidepressant treatment. One of these is trazodone, which is an antidepressant that exhibits hypnotic effect by the effect of histamine H1 re-ceptor antagonist and 5-HT2A stimulation, which is a serotonin transporter protein inhib-itor and 5-HT2A and 5HT2C antagonist. Some antidepressants can cause mania-like mood episodes when used singly or in combination. In this case report, we discussed a manic episode that developed after including trazodone for sleep problems in the treatment of a patient with an anxiety disorder who uses escitalopram.