Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2005 / Cilt: 6 - Sayı: 2
Comparsion of the effects in intranasal and transdermal estradiol plus dydrogestorone on lipids, lipoprotein (A) and apoliproteins in postmenopausal women
- Pages
- 3–8
- DOI
- —
Abstract
Objective:To compare the effects of continuous hormon replacement therapy in the form of intranasal and transdermal 17β- estradiol combined with dydrogesterone on serum lipids, lipoprotein(a) and apolipoproteins among postmenopausal women. Materials and methods: In this prospective study, 50 healthy postmenopausal women aged 43-54 years were randomly assigned to receive either 300 µg/day intranasal 17 β- estradiol (n=25) or 50 µg/day transdermal 17 β- estradiol (n=25) for 12 weeks.All women also received 10 mg/day oral dydrogesterone continuously.At the end of the study, changes in serumtotal cholesterol, triglyceride, HDL, LDL,VLDL, lipoprotein(a),Apo A-I and Apo B levels within and percent changes between the groups were compared. Mann-Whitney U and Wilcoxon tests were usedas indicated. P-values below 0.05 were considered significant.Results: Thirty-four women completed this study (intranasal group, n=16; transdermal group, n=18). In intranasal estradiol group, only apolipoprotein B levels were decreased significantly after 12 weeks of treatment (2.0±0.4 to 0.9±0.1, p=0.028) whereas no changes in the levels of total cholesterol, triglyceride, HDL, LDL, VLDL, lipoprotein(a) and ApoA-I were observed. Also, in transdermal estradiol group, no significant changes were seeninall variables.Nosignificant difference swith regard to variables were noted between the groups at the endof the study.Conclusions: The effects of intranasal and transdermal estradiol plus dydrogestorone as a continouos hormone replacement therapy on the serum total cholesterol, triglyceride, HDL, LDL, VLDL, lipoprotein(a) andApoA-I levels are similar in postmenopausal women.
Özet
Amaç: Bu araştırmanın amacı, postmenopozal kadınlarda, intranazal ve transdermal 17β-östradiol ile didrogesteronun kombine kesintisiz hormon replasman tedavisinin, serumlipid, lipoprotein(a) ve apolipoprotein düzeyleri üzerindeki etkilerini karşılaştırmaktır. Gereç ve Yöntem: Bu prospektif araştırmaya yaşları 43-54 arasında değişen, sağlıklı 50 postmenopozal kadın dahil edildi. Olgular, 12 hafta süre ile 300 µ g/gün intranazal 17 β- östradiol (n=25) veya 50 µg/gün transdermal kesintisiz verildi. Araştırmanın başında ve sonunda, total kolesterol, trigliserid, HDL, LDL, VLDL, lipoprotein(a), Apo A-I ve Apo B düzeyleri, grup içi ve gruplar arasında farkın yüzdeleri karşılaştırıldı. İstatistiksel analiz için Mann-Whitney U ve Wilcoxon testi kullanıldı. P