Two Consecutive Acute Coronary Syndrome Patients after Dinitro-Ortho-Cresol Exposure

Dinitro-Ortho-Cresol Maruziyeti Sonrasında Akut Koroner Sendrom Gelişen Ardışık İki Hasta

Ahmet Oğuz BAKTIR,Hayrettin SAĞLAM,Bahadır ŞARLI,Hüseyin ARINÇ,Yasemin DOĞAN,Hüseyin KATLANDUR

Abstract

Nitrophenols are common components of industrial effluents and have been detected in urban and agricultural waste. Dinitroortho-cresol (DNOC) can easily enter the body through inhalation, ingestion or the skin. Yellow staining is typical in toxications via skin contact. The main toxic effects of DNOC derivatives are due to an increase in cellular metabolism. It acts directly on metabolism by inducing cellular oxidation and inhibiting phosphorylation, leading to the uncoupling of oxidative phosphorylation. Cardiovascular effects appear to be secondary to cellular anoxia. We report here two consecutive patients admitted to the emergency department with an initial diagnosis of toxic exposure to DNOC. Further examination revealed that toxic exposure led to simultaneous acute coronary syndrome

Özet

Nitrophenols are common components of industrial effluents and have been detected in urban and agricultural waste. Dinitro-ortho-cresol (DNOC) can easily enter the body through inhalation, ingestion or the skin. Yellow staining is typical in toxications via skin contact. The main toxic effects of DNOC derivatives are due to an increase in cellular metabolism. It acts directly on metabolism by inducing cellular oxidation and inhibiting phosphorylation, leading to the uncoupling of oxidative phosphorylation. Cardiovascular effects appear to be secondary to cellular anoxia. We report here two consecutive patients admitted to the emergency department with an initial diagnosis of toxic exposure to DNOC. Further examination revealed that toxic exposure led to simultaneous acute coronary syndrome.

Keywords: 2,4-Dinitrofenol,akut koroner sendrom,2,4-Dinitrofenol toksik maruziyeti,DNOC