ANTIMUSCARINIC EFFECTS OF AMITRIPTYLINE HCI AND OPIPRAMOLE HCI IN RAT ILEUM AND RAT DUODENUM

Abstract

Arnitriptyline, a tricyclic antidepressant which is mainly used for major depression treatment, was investigated about its antimuscarinic effects and as a result it was found generally non-selective and 100 fold less active than atropine (1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinic activity and selectivity. Experiments were based on measuring agonist and antagonist responses in isolated tissues in physiological conditions.

Özet

Arnitriptyline, a tricyclic antidepressant which is mainly used for majordepression treatment, was investigated about its antimuscarinic effects and as aresult it was found generally non-selective and 100 fold less active than atropine(1,2,3,4). There are no satisfactory information about opipramole's antirnuscarinicactivity and selectivity.Experiments were based on measuring agonist and antagonist responses inisolated tissues in physiological conditions.Key words: Antimuscarinic activity, Tricyclic antidepressants, Arnitriptyline,Opipramole.