SOME IMIDAZO[1,2-α] PYRIDINE DERIVATIVES AS POSSIBLE ANTIMYCOBACTERIALS

Abstract

Some new hydrazide-hydrazones and 4-thiazolidinones incorporating an imidazo[l,2-α]pyridine moiety were synthesized and the new and structurally related compounds which were previously reported were screened for antituberculosis activity.The treatment of tuberculosis is still one of the major problems due to the rise of multidrug-resistant tuberculosis in clinical p;actise. In our previous stud- ,ies ,(l-3) we described the synthesis of &idazo[l,2-alpyridine-3-.c~bohydrazides and related compounds, which are structurally sdar to iso&cotinic acid hydrazide (INH), the principal drug for the treatment of tuberculosis. As a con-

Özet

hidazo[l,2-alpiridin art^& tapyan baz~ yeni hidrazid-hidrazon ve 4- tiyazolidinon yaplslndaki bilegiklerin sentezleri yapd.rmg, yeni bilesiklerin ve daha once bildirilmis yap~sal benzerlilcteki bilegiklerin antitiiberkiiloz etkileri aragtmlrmgtlrhidazo[l,2-alpiridin art^& tapyan baz~ yeni hidrazid-hidrazon ve 4- tiyazolidinon yaplslndaki bilegiklerin sentezleri yapd.rmg, yeni bilesiklerin ve daha once bildirilmis yap~sal benzerlilcteki bilegiklerin antitiiberkiiloz etkileri aragtmlrmgtlrhidazo[l,2-alpiridin art^& tapyan baz~ yeni hidrazid-hidrazon ve 4- tiyazolidinon yaplslndaki bilegiklerin sentezleri yapd.rmg, yeni bilesiklerin ve daha once bildirilmis yap~sal benzerlilcteki bilegiklerin antitiiberkiiloz etkileri aragtmlrmgtlr

Keywords: hydrazide-hydrazones, thiosemicarbazides, 4-thiazolidinones imidazo[l,2-a]pyridine, antituberculosis activity