Non-astmatic Eosinophilic Bronchitis

Özet

Non-asthmatic eosinophilic bronchitis (NAEB) is eosinophilic inflammation of the respiratory tract, without any bronchospasm. In this ar-ticle, we want to draw attention to the NAEB. It should also be considered in differential diagnosis of chronic cough. Eosinophilia is pres-ent in all induced or spontaneous sputum samples of NAEB patients. NAEB patients and asthmatic patients have similar airway inflam-mation. Remarkably, NAEB mainly occurs in the lower airways. Unlike asthma, mast cells in NAEB are active in the bronchial epithelium.Diagnosis is based on the clinical, radiological, and spirometric measurements of other causes of chronic cough (Post-nasal dischargesyndrome, asthma, gastroesophageal reflux etc.) and the assessment of inflammation in the lower respiratory tract. Airway inflammationcan be assessed by sputum induction. The main treatment is anti-inflammatory therapy with inhaled corticosteroids and taking protectivemeasures if inflammation is due to occupational exposure or allergen inhalation. If NAEB is untreated, it may be transient, episodic, orpersistent; rarely, long-term oral steroid treatment may be required in patients. There is a requirement for studies that investigate the roleof non-invasive markers of chronic inflammation associated with NAEB and the effectiveness of other treatments.