Angiotensin-Converting Enzyme Inhibitors Induce Cough

Özet

Angiotensin-converting enzyme inhibitors (ACE-I) are widely used in diseases, such as hypertension, congestive heart failure, and myocardial infarction. Although these drugs are well tolerated, one out of five patients discontinues ACE-I due to drug side effects, mainlychronic cough. However, the pathogenesis of ACE-I-induced cough remains controversial and requires further study. In this review, themechanisms that are suggested in ACE-I-induced cough pathophysiology will be discussed in detail in light of the current literature.