Light Microscopic Evaluation of Acute and Chronic Hypophyseal Endocrinopathy in a Kaolin-Induced Hydrocephalus Model

Özet

AIM: To demonstrate progression of acute and chronic endocrinopathies in a kaolin-induced hydrocephalus model using lightmicroscopy.MATERIAL and METHODS: Adult male Sprague–Dawley rats (n = 48) were divided into six groups. Hydrocephalus was inducedby intracisternal injection of kaolin solution in the acute and chronic kaolin groups, whereas an identical volume of sterile saline wasinjected into the sham groups.RESULTS: Somatotropic cell concentrations were lower in the kaolin groups compared with their controls, but there was nodifference in somatotropic cell concentration between the acute and chronic kaolin groups. Corticotropic cell concentrations werehigher in the acute kaolin and sham groups compared with acute controls. Thyrotropic cell numbers were higher in the acute shamand kaolin groups compared with their controls, and although thyrotropic cell concentations were higher in the acute kaolin groupthan the acute sham group. No differences were observed between the acute and chronic controls and sham and kaolin groupsregarding mammotropicand gonadototropic cell concentations.CONCLUSION: Somatotropic cells are most affected by hydrocephalus that causes pituitary dysfunction, and this effect was moreprominent under acute and chronic phases.