Is antibiotic lock therapy effective for the implantable longterm catheter-related bloodstream infections in children?

Özet

Catheter-related bloodstream infections (CRBSIs) are an important problemin pediatric patients with central venous catheters. This study aimed todetermine the incidence of CRBSIs, responsible pathogens and outcomes ofantibiotic lock treatment (ALT) in pediatric patients. Between January 2010and November 2015 all hospitalized pediatric hematology, oncology andimmunology patients diagnosed with CRBSIs were retrospectively analyzed.Seventy-eight CRBSI episodes were detected in 60 pediatric patients. Theincidence of CRBSIs was 4.20/1000 catheter days. The most frequentlydetected pathogen was methicillin-resistant coagulase-negative Staphylococcus.Pseudomonas aeruginosa, Klebsiella spp., and Escherichia coli were other commonlyisolated microorganisms. ALT was administered in 42 patients. The successrate of ALT was 81% (34/42). Catheter was removed without ALT in 36episodes. Common reasons for catheter removal were sepsis and causativemicroorganisms which had high probability of biofilm formation.CRBSIs are an important cause of morbidity and mortality in pediatricpatients. ALT is safe and effective. It is possible to obtain satisfactory resultswhen ALT is used with intravenous systemic antibiotics for CRBSIs, though insome cases catheter removal is necessary. ALT helps to prevent unnecessarycatheter removal in pediatric patients.