Beneficial effect of synbiotics on experimental colon cancer in rats

Özet

Background/Aims: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and aprebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats.Materials and Methods: Sixty male rats were categorized into three groups of 20 animals each. Group A was administered1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks. Group B was administered 1,2-dimethylydrazine at thesame dose plus synbiotic, started after the second dose of carcinogen and lasted for 5 weeks. Group C was administered synbiotic pluscarcinogen from the beginning of the experiment and lasted for 7 weeks. Animals were killed at the end of week 7.Results: At the end of the experiment, the animals that received carcinogen plus the synbiotic had 100%, whereas the animals thatreceived only carcinogen has 70% survival. Animals of groups B and C had significantly lower percentage of inflammation, colitis-likelesions, and ACF dysplasia than animals of group A, whereas those of group C had the least pathological lesions.Conclusion: Synbiotics seem to protect against the appearance of preneoplastic colon lesions in rats. The results of this experimentalstudy suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development ofpreneoplastic lesions in rats.