How would serum 25(OH)D level change in patients with inflammatory bowel disease depending on intestinal mucosa vitamin D receptor (VDR) and vitamin D1-α hydroxylase (CYP27B1)?

Özet

Background/Aims: To investigate how the serum 25-hydroxyvitamin D (25(OH)D) level change in patients with inflammatory boweldisease (IBD) and investigate the intestinal mucosa vitamin D receptor (VDR) and vitamin D1-α hydroxylase (CYP27B1) expressions.Materials and Methods: A total of 105 patients with IBD were enrolled in the present study, including 49 cases with ulcerative colitis (UC)and 56 cases with Crohn’s disease (CD), compared with 45 healthy controls (CON) during the same period by testing the permeability ofthe intestinal mucosa. The expressions of VDR and CYP27B1 in the intestinal mucosa were detected, so as the serum endotoxin, tumornecrosis factor (TNF)-α, and 25(OH)D levels.Results: The lactulose and mannitol absorption ratio (LMR) and serum endotoxin and TNF-α levels were significantly higher in the IBDgroup than in the CON group (p 0.05). CYP27B1 in the IBD and CD groups was significantly up-regulated compared with the CONgroup (p 0.05).Conclusion: Patients with IBD exhibit vitamin D metabolism imbalance, lower serum 25(OH)D, and lower VDR expression, but higherCYP27B1 expression in the colonic mucosa. However, VDR and CYP27B1 cannot be used to distinguish UC and CD.