Can a 1-day clear liquid diet with a split -dose polyethylene glycol overcome conventional practice patterns during the preparation for screening colonoscopy?

Özet

Background/Aims: A successful screening colonoscopy is closely linked to the quality of a bowel preparation. In this study, we aimed todetermine the impact of a 1-day clear liquid diet (CLD) compared to a 3-day combined diet (CMD) accompanied by a split-dose regimenof polyethylene glycol and electrolyte lavage solution (PEG-ELS) for screening colonoscopy.Materials and Methods: This was a prospective, randomized, endoscopist-blinded study. Patients referred for screening colonoscopywere randomized to four groups as a 1-day CLD+PEG-ELS vs. a 1-day CLD+sulfate free (SF)-PEG-ELS and a 3-day CMD+PEG-ELS vs. a3-day CMD+SF-PEG-ELS. An assessment of the quality of colon cleaning, tolerability to the preparation, and symptoms related to thepreparation were recorded.Results: A total of 506 patients were enrolled in this study. The quality of bowel preparation was significantly inferior in the CMD+PEG-ELS group than CLD+PEG-ELS (p=0.004) and CMD+SF-PEG-ELS groups (p=0.007). There were no statistical differences amongthe groups in terms of the polyp detection rate. With respect to an easy rating of diet following and the consumption of laxative, therewere no significant differences among the four groups. Gastric fullness and nausea/vomiting were pointed out much more, especially inthe SF-PEG-ELS users (p=0.008 and p=0.004, respectively).Conclusion: A 1-day CLD was not inferior to a 3-day CMD for colonoscopy preparation in terms of bowel cleaning, the polyp detectionrate, and patient tolerance.