The Research Progress of Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury

Özet

Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgentto ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution afterdrug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineagedifferentiation properties. They are favorable for the treatment of various diseases and injuries. It could be envisioned that MSCstransplantation may be a promising treatment for TBI. Currently, stem cell therapy has shown promising effects in the treatment ofmany diseases. In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties ofimmune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs, and the safety issues inMSCs therapy in TBI.