Management of Hardware Related Infections after DBS Surgery: A Cost Analysis

Özet

AIM: To investigate the costs of treating the infection with antibiotics only with the risk of surgery when unsuccessful versusimmediate removal followed by re-implantation in patients with deep brain stimulation (DBS) hardware infection.MATERIAL and METHODS: We calculated the costs of the different strategies through a standard costing procedure. A decisionmodel has been applied to establish the average treatment cost per patient representative for a clinical setting where both strategiesare employed. Subsequently, a sensitivity analysis has been performed to assess the influence of clinical assumptions regarding theeffectiveness of antibiotics treatment on average treatment costs.RESULTS: The costs of treating a case of DBS hardware infection with immediate internal pulse generator (IPG) replacementsurgery were €29,301 compared to €9499 for successful antibiotic treatment. For antibiotic treatment followed by IPG replacementsurgery the total costs were €38,741. Antibiotic treatment alone was successful in 44% (4/9) of the included cases of DBS infection,resulting in average treatment costs per patient of €25,745. Trying to resolve DBS hardware infections initially with antibioticsreduced treatment costs by 12.1%.CONCLUSION: Treatment with antibiotics with the risk of a later removal when unsuccessful was a more valuable strategy in termsof costs when compared to immediate surgical intervention in cases of hardware-related infections in DBS surgeries.