Accuracy of Frozen-Section Diagnosis of Brain Tumors: An 11-Year Experience from a Tertiary Care Center

Özet

AIM: To analyze the frozen section (FS) diagnostic accuracy in correlation with the final diagnosis of brain tumors.MATERIAL and METHODS: This retrospective study comprised all brain tumor cases with FS diagnosis and permanent sectiondiagnosis in Jordan University Hospital from July 1, 2007 to December 31, 2017. Data were obtained by reviewing slides and reportsfrom the histopathology archives. Statistical Package for the Social Science (SPSS) software v20 was used for analysis.RESULTS: A total of 179 cases with frozen section and permanent section diagnoses were analyzed. Eighty-four (47%) patientswere males and 95 (53%) females.The ages ranged from 1 to 85 years. Diagnostic accuracy of FS was 88.8%. Discrepancy wasnoted in 20 cases. Of the discrepancies, misclassification of tumor type was the most common category (12 cases, 60%), followedby grading mismatch (7 cases, 35%) and misdiagnosis of tumor versus non-tumor conditions (1 case, 5%). Patient age and genderwere not significantly associated with the discrepancy between FS and final diagnosis.CONCLUSION: Our results were comparable to international reports. However, more emphasis on diagnostic cytology inintraoperative consultation is required as an effective adjunct to frozen section to overcome limitations.