Effect of Curcumin on the Formation of Epidural Fibrosis in an Experimental Laminectomy Model in Rats

Özet

AIM: To clarify the effects of topical application of curcumin on the prevention of epidural fibrosis.MATERIAL and METHODS: Twenty-one rats were randomly divided into three equal groups (control, spongostan, local curcumin)and a laminectomy procedure was performed between T11 and L1 in all rats. Subsequently, spongostan soaked with curcumin(100 mg/kg) was applied topically. After four weeks, the vertebral column from T9 to L3, which included the paraspinal musclesand epidural scar tissue, was removed as a single piece and the epidural fibrosis and arachnoidal scarring were graded andhistopathological analysis carried out accordingly. Kruskal-Wallis and Pearson Chi-Square tests were used for statistical analysis.A p-value of less than 0.05 was considered to be significant.RESULTS: The grading of epidural fibrosis was far lower in the experimental group with curcumin compared to the control andspongostan groups, but the difference was not statistically significant.CONCLUSION: The findings of this study show that local curcumin decreases the formation of epidural fibrosis and this effectof curcumin is thought to be mediated by reducing the functions of inflammatory cells such as macrophages, neutrophils andfibroblasts, and the anti-inflammatory and antioxidant effects.