Metastatic Gallbladder Carcinoma in Meningioma: A Case Report

Özet

Metastases from tumors to systemic cancers are rare. The most common intracranial recipient tumor is meningioma. Metastasisfrom gallbladder cancer has been previously reported from only one patient during autopsy. We present a case of a 72-year-oldwoman who underwent surgery for right frontal skull base meningioma. The tumor was completely removed. Histological specimensshowed gallbladder carcinomatous metastasis with diffuse neuroendocrine differentiation in meningothelial meningioma. The Ki-67proliferation index of the meningioma was 3%. Further, 60% positive immunoreactivity with the progesterone receptor was observedin meningioma cells. In carcinoma cells, diffuse positive immunoreactivity with chromogranin, CDX2, CEA, panCK, cytokeratin 7,and synaptophysin was observed. A combination of molecular, metabolic, immunological, and/or hormonal factors may contributeto the pathogenesis of this lesion. It cannot be ruled out that it is more common than expected.