The Relationship Between Pain and Vitamin D in Parkinson’s Disease

Özet

Objective: Pain is one of the most common non-motor symptoms in patients with Parkin- son’s disease, and sometimes the complaint of refractory pain adversely affects the quality of life. The relationship between vitamin D and many types of pain, especially musculoskeletal pain, has been emphasized in different studies. Methods: The demographic data of 43 idiopathic Parkinson’s patients who were above stage 3 according to the Hoehn and Yahr scale, with MMSE 25 and above, not diagnosed with dementia, and without any disease and drug use affecting the vitamin D level, the UPDRS motor subscale, the nonmotor symptom scale and the shortened geriatric depression scale, were recorded. The relationship between vitamin D level and pain was evaluated. Results: Of the patients included in the study, 24 were male and 19 were female. The mean age of the patients was 61.9 (±9.84) years. The mean disease duration was 3.9 years; the mean UPDRS motor score was 18.3 (±7.6). According to the nonmotor symptom scale, the patients scored 10.2 (±5.3) out of 30. 60.5% of the patients had pain complaints. No significant relationship was found between pain and vitamin D level, age, disease duration, UPDRS, drug dose, nonmotor symptom score, GDS, (p>0.05). A significant difference was found between the levodopa doses of patients aged 60 years and younger, with and without pain (p=0.04). Patients with pain had higher levodopa doses than those without pain. A sig- nificant positive correlation was found between the presence of pain and UPDRS in patients over 60 years (p=0.035). Conclusion: As a result of the study, no relationship was found between pain and vitamin D levels. In larger patient populations, it was considered to be important to examine the relationship between pain and Vitamin D levels by identifying pain subtypes