Analysis of risk factors affecting coagulopathy after donor hepatectomy in a newly established liver transplant center

Özet

Objective: As might be expected, living donor liver surgery is associated with serious morbidity and mortality risks.Coagulopathy after donor hepatectomy is an important risk factor affecting morbidity. In this study, risk factorsaffecting the development of coagulopathy after donor hepatectomy was evaluated in a newly-established livertransplant center.Material and Methods: A retrospective evaluation of 46 liver donors to whom hepatectomy was applied in MedipolUniversty of School of Medicine Department of Organ Transplantation between April 2014 and July 2015 was made.Coagulopathy was defined as prothrombin time ≥15 sec. or platelet count <80000/mm3 on postoperative day 3.Donors were separated into 2 groups as those with (n=24) and without (n=22) coagulopathy. Preoperative, intraoperative and postoperative factors acting on coagulopathy were analyzed.Results: In the intergroup analysis, it was seen that remnant liver volume, remnant liver volume % and remnant liver volume to body weight ratio were factors associated with coagulopathy. The cut-off values for these 3 parameterswere calculated as 773.5cm3, 40.5% and 0.915 cm3/kg, respectively. Only remnant liver volume % was determined asa risk factor for coagulopathy after donor hepatectomy on multiple logistic regression analysis.Conclusion: The results of this study showed that the most important risk factors affecting coagulopathy after donorhepatectomy were the parameters associated with remnant liver volume.