Journals / Turkish Journal of Veterinary and Animal Sciences / 2001 / Cilt: 25 - Sayı: 4
Evaluation of Clinical Findings, Some Hematological and Biochemical Findings, and Age and Sex Status in Feline Immunodeficiency Virus (FIV) Seropositive Cats With Clinical Symptoms and Without Clinical Symptoms
- Pages
- 409–419
- DOI
- —
Abstract
This study was performed to investigate the clinical findings, some hematological and biochemical findings, and sex and age status in feline immunodeficiency virus (FIV) seropositive cats. In 37 FIV-seropositive cats, different clinical symptoms were observed (group 1). However, seven of the FIV-seropositive cats showed no clinical symptoms (group 2). The control group was made up of 116 healthy cats. FIV infection was seen more in male cats (78.4%) than in female cats. 62% of the FIV-seropositive cats were over 5 years old. Group 1 of FIV-seropositive cats showed symptoms of stomatitis/gingivitis (21.6%), extreme weight loss (10.8%), chronic infection in the respiration ways (10.8%), anemia (13.5%), swollen lymph nodes (8.1%), tumors (5.4%), disease of eyes (5.4%), anorexia (13.5%), limping (8.1%), uremia (13.5%), diarrhea and vomit (5.4%), dermatitis (5.4%) and cardiomyopathy (5.4%). When the biochemical parameters of group 1 were compared with those of the control group, the enzyme activities of ALT and GLDH, and the concentrations of plasma bilirubin, total protein, urea and potassium were significantly increased (p<0.05). The concentrations of plasma total calcium were significantly decreased (p<0.01), and the plasma concentrations of natrium were lower than the reference range in 21.6% of the cats in group 1. The hematological parameters of group 1 were compared with those of the control group, and the thrombocyte count was found to be significantly decreased (p<0.01), and the leucocyte count significantly increased (p<0.01). However, all cats with leucocytosis showed lymphopenia, and 5.4 % of group 1 of FIV- seropositive cats had leucopenia. There were no significant differences in erythrocyte count and hematocrit value between group 1 and the control group. However, the erythrocte count and the hematocrit values were lower than the reference range in 13.5% of group 1 FIV-seropositive cats. The concentration of plasma total protein (p<0.01), and potassium (p<0.05) were significantly increased; however, the concentration of plasma calcium was significantly (p<0.01) lower in group 2 of FIV- seropositive cats compared with the control group. Thrombocytopenia (n=1, and significant decrease p<0.01) and leucopenia (n=2) were also seen in group 2 of FIV-seropositive cats.
Özet
Araflt›rma, felin immun yetmezlik virusu’nun (FIV) seropozitif oldu¤u kedilerde, klinik, baz› hematolojik ve biyokimyasal bulgular ile yafl ve cinsiyet durumlar›n›n incelenmesini amaçlam›flt›r. FIV seropozitif kedilerin 37'si de¤iflik klinik belirtiler gösteren kedilerden (1. grup), 7’si ise klinik belirti göstermeyen kedilerden (2. grup) oluflmufltur. Toplam 116 sa¤l›kl› kedi de kontrol grubu olarak al›nm›flt›r. FIV infeksiyonu özellikle erkek kedilerde (% 78,4) diflilere göre daha fazla görülmüfltür. FIV seropozitif kedilerin %62'sinin 5 yafl›n üstünde oldu¤u gözlenmifltir. Birinci grupdaki FIV seropozitif kedilerde stomatitis/gingivitis (%21,6), afl›r› kilo kayb› (%10,8), kronik üst solunum yolu infeksiyonu (%10,8), anemi (%13,5), lenfadenopati (%8,1), tümöral hastal›k (%5,4), göz hastal›klar› (%5,4), ifltahs›zl›k (%13,5), topallama (%8,1), apati (%18,9), üremi (%13,5), ishal ve kusma (%5,4), dermatitis (%5,4) ve kardiyomyopati (%5,4) gibi klinik belirtiler tespit edilmifltir. Birinci grupdaki FIV seropozitif kedilerin biyokimyasal parametrelerini kontrol grubu ile karfl›laflt›rd›¤›m›zda, ALT ve GLDH enzim aktiviteleri, plazma bilirubin, total protein, üre ve potasyum konsantrasyonlar› önemli derecede yüksek (p< 0,05), total kalsiyum düflük (p<0,01) ve sodyum iyon konsatrasyonlar› ise bu kedilerin %21,6’s›nda normal de¤erlerden düflük oldu¤u saptanm›flt›r. Bu grupdaki kedilerin hematolojik parametrelerini kontrol grubu ile karfl›laflt›rd›¤›m›zda, trombosit say›lar› düflük (p<0,01), lökosit say›lar› ise yüksek (p<0,01) ç›kmas›na karfl›n, kedilerin % 5,4’ünde lökopeni ve lökositoz gösteren kedilerin hepsinde lenfopeni saptanm›flt›r. Birinci grupdaki kedilerin eritrosit ve hematokrit de¤erleri kontrol grubu karfl›s›nda farks›z ç›km›flt›r, fakat kedilerin %13,5’inde eritrosit say›s›n›n ve hematokrit de¤erinin normal de¤erinden düflük oldu¤u saptanm›flt›r. ‹kinci grupdaki FIV seropozitif kedilerin kontrol grubu karfl›s›nda plazma total protein (p<0,01) ve potasyum konsantrasyonlar› (p<0,05) yüksek, kalsiyum konsantrasyonu ise (p<0,01) düflük ç›km›flt›r. Bu kedilerde trombositopeni (n=1 ve önemli derecede düflük p<0,01) lökopeni de (n=2) tespit edilmifltir.