Journals / Turkish Journal of Chemistry / 2003 / Cilt: 27 - Sayı: 5
DNA Cleavage Activity of Diazonium Salts: Chemical Nucleases
- Journal
- Turkish Journal of Chemistry
- Pages
- 539–544
- DOI
- —
Abstract
4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copper(II) chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.
Özet
4-Fenoldiazonium tetrafluoroborate and 4-benzoicaciddiazonium tetrafluoroborate was prepared and was shown to be an effective DNA cleavage agent in the presence of the 1-electron donor copper(II) chloride. Its mechanism involves the generation of the aryl radical cleaving DNA by hydrogen atom abstraction from deoxyribose sugar.