Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial

Özet

Objective: This trial investigated the post operative analgesic efficacy of oarl etoricoxib 90 mg and 120 mg and a placebo in mandibular fracturepain model.Methods: A total of 63 adult patients with mandibular fractures who were scheduled to undergo maxillofacial surgery were randomly allocatedto receive etoricoxib 90 mg, etoricoxib 120 mg and a placebo 1 hour before the surgery. Patients were followed-up till 24 hours after the surgery.Duration of analgesia, intra-operative and post-operative analgesic requirement, pain score, post-operative patient satisfaction and adverseeffects were measured.Results: The baseline demographic parameters were similar in all the groups. Duration of analgesia was longer in both the E120 (6.00±0.816hours) and E90 (4.37±1.008 hours) groups (p 0.05). Post-operative pain intensity was significantly lowerin both the E120 and E90 groups as compared to the C group. Both the etoricoxib groups required less intra-operative (p=0.002) and post-operative (p=0.001) analgesic supplementation as compared to the placebo group. The patient satisfaction score and rate of occurrence of significantadverse effects were similar among all the three groups.