Comparison of Haemodynamic Response to Inhalational Bolus with Desflurane in Normotensive and Hypertensive Patients Undergoing Laparoscopic Cholecystectomy

Özet

Objective: Desflurane causes sympathetic stimulation at high end-tidal concentrations. We conducted this study to compare the haemodynamicresponse to inhalational bolus with desflurane in normotensive and hypertensive patients undergoing laparoscopic cholecystectomy.Methods: In this prospective, clinical trial, 40 patients aged 18-60 years and undergoing laparoscopic cholecystectomy were divided into normotensives (Group N; n=20) and hypertensives (Group H; n=20). Heart rate (HR), mean arterial pressure (MAP) and bispectral index (BIS) weremeasured at baseline and every 60 s for 5 min after induction, intubation, initiation and inhalational bolus of desflurane. The primary objectivewas to compare haemodynamic response, and the secondary objective was to assess the need for inhalational boluses and to compare the numberof overcorrections and undercorrections in BIS value after each inhalational bolus. An independent t-test was used to compare the means of thestudy parameters between the groups, and a dependent t-test was used to compare the percentage change in the means of the study parameterswithin the same group. Statistical significance was defined as p 55).Conclusion: BIS-guided desflurane administration and BIS-triggered inhalational boluses of desflurane is safe, feasible and does not causesympathetic stimulation in either normotensive or hypertensive patients.