Perioperative Comparison of Preemptive and Non-Preemptive Renal Transplant Recipients

Özet

Objective: Preemptive transplantation cannot be performed for all patients because of the limited number of donors. This study aimed toevaluate the perioperative effects of dialysis before renal transplantation.Methods: In this study, we retrospectively investigated 666 patients who underwent kidney transplantation at our centre. We divided patientsinto two groups: patients with pre-transplant dialysis (67.3%, n=448) and patients with preemptive transplant (32.7%, n=218). We carried outpreoperative, intraoperative and postoperative comparisons between groups.Results: No difference was observed in terms of intraoperative blood transfusion, crystalloid and colloid requirement, inotropic-vasopressoragent administration and hemodynamic parameters between the patients with pre-transplant dialysis and preemptive transplant. It was observedthat dialysis requirement, delayed graft function and acute rejection development were significantly higher during the postoperative period inpatients who underwent dialysis before transplantation. In patients with non-preemptive transplant, the decrease of serum creatinine levels atthe first postoperative month was more prominent when compared to patients with preemptive transplant; however, that difference disappearedin the first year follow-up. No significant difference was found for serum albumin levels and proteinuria alterations of the patients in long-termfollow-up. Additionally, patient and graft survival comparisons between patients with non-preemptive and preemptive transplant on three-yearfollow-up revealed no significant difference.Conclusion: We think that preemptive transplantation treatment is a better option for patients with end-stage renal failure since patients withpreemptive transplantation appear to have less metabolic function impairment, complication risk and more successful outcomes in terms ofcost-effectiveness.